TP63, SOX2 and KLF5 Establish Core Regulatory Circuitry and Construct Cancer Specific Epigenome in Esophageal Squamous Cell Carcinoma
Y. Jiang, Y. Jiang, C.-Q. Li, Z. Ying, P. Dakle, J.-W. Deng, R. Y.-T. Lin, H. Kaur, L. Han, J.-J. Xie, A. Mayakonda, M. Hazawa, L. Xu, Y. Li, L. Aswad, , H. P. Koeffler
This study identifies TP63, SOX2, and KLF5 as core regulatory circuitry transcription factors in ESCC that drive epigenetic modifications and tumor growth through super-enhancer interactions.
bioRxiv · Nov 6, 2019 · PreprintCancer Biology