Author

D.-C. Lin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 7

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Organism:human· 7 Research Focus:gene regulatory network inference· 5 Approach:statistical model· 5 Assay:ChIP-seq· 4 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:differential expression· 3 Assay:DNA methylation· 3 Approach:experimental assay· 3

Frequent Co-Authors

H. P. Koeffler· 4 shared Y. Zheng· 4 shared B. P. Berman· 3 shared B. Ziman· 2 shared E.-M. Li· 2 shared L.-Y. Xu· 2 shared Q. Yang· 2 shared S. Gery· 2 shared

Activity by Year

2019-2022 · peak 3/yr

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10 top collaborators · 32 mutual co-author links

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4 shared papersCancer Biology

H. P. Koeffler

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7 papers

Recent·Most cited

Comprehensive analyses of partially methylated domains and differentially methylated regions in esophageal cancer reveal both cell-type- and cancer-specific epigenetic regulation

Y. Zheng, B. Ziman, A. S. Ho, U. K. Sinha, L.-Y. Xu, E.-M. Li, B. P. Berman, D.-C. Lin

This study identifies cell-type- and cancer-specific epigenetic features in esophageal cancer using whole-genome bisulfite sequencing, revealing novel insights into DNA methylation dynamics.

bioRxiv · Aug 18, 2022Cancer Biology

Novel tumorigenic FOXM1-PTAFR-PTAF axis revealed by multi-omic profiling in TP53/CDKN2A-double knockout human gastroesophageal junction organoid model

H. Zhao, Y. Cheng, A. Kalra, K. Ma, Y. Zheng, B. Ziman, C. Tressler, K. Glunde, E. J. Shin, S. Ngamruengphong, M. Khashab, V. Singh, R. A. Anders, S. Jit, N. Wyhs, , S. J. Meltzer

bioRxiv · May 10, 2022 · PreprintCancer Biology

A pan-cancer analysis of CpG Island gene regulation reveals extensive plasticity within Polycomb targets

Y. Zheng, G. Huang, T. C. Silva, Q. Yang, H. P. Koeffler, B. P. Berman, D.-C. Lin

The paper analyzes CpG Island gene regulation across cancers, finding that PRC2+-CGI genes show both upregulation and hypermethylation in different cancer types, indicating regulatory plasticity.

bioRxiv · Jun 4, 2020Cancer Biology

EWS-FLI1 regulates and cooperates with core regulatory circuitry in Ewing sarcoma

X. Shi, Y. Zheng, L. Jiang, B. Zhou, W. Yang, L. Li, L. Ding, M. Huang, S. Gery, D.-C. Lin, H. P. Koeffler

This study identifies and validates a core regulatory circuitry trio in Ewing sarcoma, showing how EWS-FLI1 and CRC factors regulate transcription and epigenome, with implications for therapy.

bioRxiv · Jan 15, 2020Cancer Biology

Predicting master transcription factors from pan-cancer expression data

J. Reddy, M. A. S. Fonseca, R. I. Corona, R. Nameki, F. Segato Dezem, I. A. Klein, H. Chang, D. Chaves-Moreira, L. Afeyan, T. M. Malta, X. Lin, F. Abbasi, A. Font-Tello, T. Sabedot, P. Cejas, , K. Lawrenson

This paper introduces CaCTS, an algorithm that identifies candidate master transcription factors (MTFs) across 34 cancer types using RNA-seq data, revealing novel MTFs and functional groupings.

bioRxiv · Nov 12, 2019Cancer Biology

TP63, SOX2 and KLF5 Establish Core Regulatory Circuitry and Construct Cancer Specific Epigenome in Esophageal Squamous Cell Carcinoma

Y. Jiang, Y. Jiang, C.-Q. Li, Z. Ying, P. Dakle, J.-W. Deng, R. Y.-T. Lin, H. Kaur, L. Han, J.-J. Xie, A. Mayakonda, M. Hazawa, L. Xu, Y. Li, L. Aswad, , H. P. Koeffler

This study identifies TP63, SOX2, and KLF5 as core regulatory circuitry transcription factors in ESCC that drive epigenetic modifications and tumor growth through super-enhancer interactions.

bioRxiv · Nov 6, 2019 · PreprintCancer Biology

Lineage-Specific Epigenomic and Genomic Activation of the Oncogene HNF4A Promotes Gastrointestinal Adenocarcinomas

J. Pan, T. C. Silva, N. Gull, Q. Yang, J. Plummer, S. Chen, K. Daigo, T. Hamakubo, S. Gery, L.-W. Ding, Y.-Y. Jiang, S.-Y. Hu, L.-Y. Xu, E.-M. Li, Y. Ding, , D.-C. Lin

The paper identifies lineage-specific activation of HNF4A in gastrointestinal adenocarcinomas through epigenomic and genomic analysis, revealing its role in promoting cancer proliferation.

bioRxiv · Oct 21, 2019Cancer Biology