Molecular BiologybioRxivPreprint
HnRNPAB-targeted antisense oligonucleotides ameliorate tau pathology and cognitive deficits by modulating Alzheimers disease-associated alternative splicing
Tao Jiang, Xingjun Xu, Yaqiong Yu…·Jingming Hou
This study identifies AB332, a hnRNPAB isoform, as a repressor of MAPT exon 10 inclusion and shows that targeting hnRNPAB with antisense oligonucleotides reduces tau pathology and cognitive deficits in AD mice.
DOI 10.64898/2026.07.02.736008