MicrobiologyNucleic Acids ResearchPeer-reviewed
DNA damaged-induced phosphorylation of a viral replicative DNA helicase results in inhibition of DNA replication through attenuation of helicase function
Caleb Homiski, Rama Dey-Rao, Shichen Shen…·Thomas Melendy
This study shows DDR phosphorylation of SV40 LT at T518 inhibits DNA replication by reducing helicase activity without affecting ATPase function or protein interactions.