Sex specific disruptions in Protein Kinase Cγ signaling in a mouse model of Spinocerebellar Ataxia Type 14
Sarah A. Wolfe, Yuliang Ma, Caila A. Pilo, Carly Chang, Majid Ghassemian, Amanda J. Roberts, Sang Ryeul Lee, George Gorrie, Susan Serota Taylor, Alexandra C. Newton
The paper develops a mouse model of SCA14 with a clinically relevant PKCγ mutation, identifies sex-specific disease mechanisms, and highlights potential therapeutic targets for males.
bioRxiv · Feb 10, 2025 · PreprintNeuroscience