Majid Ghassemian

The paper determines the high-resolution structure of the Chimalliviridae phage Goslar, revealing its host recognition and infection machinery through cryo-EM and mass spectrometry.

The paper shows that Chimalliviridae form a lipid membrane-bound EPI vesicle during early infection, which hosts transcription of the phage genome, and demonstrates the necessity of a second compartment, the phage nucleus, for genome replication.

The paper develops a mouse model of SCA14 with a clinically relevant PKCγ mutation, identifies sex-specific disease mechanisms, and highlights potential therapeutic targets for males.

This study shows PKC theta sustains T cell function while PKC eta drives terminal exhaustion, with distinct downstream cascades and therapeutic implications for cancer immunotherapy.

This study shows that neuronal activity increases mitochondrial O-GlcNAcylation, which helps neurons meet energy demands based on fuel availability.

This study identifies ChmC, a phage protein that binds RNA and facilitates mRNA transport through the phage nucleus-like compartment, essential for infection.

This study identifies OGT-mediated O-GlcNAcylation of HK1 as a mechanism regulating glycolytic metabolon assembly on mitochondria, enhancing ATP production and synaptic function.