Connor DesRoberts

Rationally Engineered Self-Assembling Protein Nanoparticles for Allergen-Specific Peanut Allergy Immunotherapy

This paper develops self-assembling protein nanoparticles displaying peanut allergens to treat peanut allergy, showing robust protection in both prophylactic and therapeutic settings.

Xenoglycosylation of the HIV-1 Glycan Shield Promotes Cross-Clade Neutralization and Diverse Human Antibody Lineages

This study shows that xenoglycosylation of HIV-1 Env with core (1,3)-fucose enhances cross-clade neutralization and diversifies human antibody lineages.

Single-component self-assembling protein nanoparticles displaying stabilized prefusion-closed hemagglutinin trimers for influenza vaccine development

This study designs stabilized HA trimers on self-assembling protein nanoparticles to improve influenza vaccine efficacy by enhancing immunogenicity and lymph node retention.

Native-like soluble E1E2 glycoprotein heterodimers on self-assembling protein nanoparticles for hepatitis C virus vaccine design

The paper designs, characterizes, and tests a soluble HCV E1E2 heterodimer and self-assembling nanoparticles for vaccine development.

Rational design of next-generation filovirus vaccines through glycoprotein stabilization, nanoparticle display, and glycan modification

This study rationally designs and characterizes filovirus glycoproteins and nanoparticles in vitro and in vivo to aid vaccine development.

Polycomb response elements reduce leaky expression of Cas9 under temperature-inducible Hsp70Bb promoter in Drosophila melanogaster

The paper shows Polycomb response elements reduce leaky Cas9 expression under a heat-inducible promoter in Drosophila, but further regulation is needed for precise control.