Obesity Impairs the Antitumor Activity of CAR-T Cells in Triple-Negative Breast Cancer
Hannah M. Malian, Caroline Marnata, Hannah M. Oh, Elaine M. Glenny, Alyssa N. Ho, Gianpietro Dotti, Stephen David Hursting, Michael F. Coleman
This study shows obesity impairs B7-H3.CAR-T cell antitumor activity and memory formation in TNBC by altering cytokine profiles and metabolic function.
npj Breast Cancer · Sep 29, 2026Peer-reviewedCancer Biology