Gianpietro Dotti

This study shows obesity impairs B7-H3.CAR-T cell antitumor activity and memory formation in TNBC by altering cytokine profiles and metabolic function.

This study shows that IL-12 enhances the anti-glioblastoma efficacy of GD2-targeted CAR-T and CAR-iNKT cells by improving their persistence and function after repeated antigen exposure.

This study shows NG2-targeting CAR-Ms engulf glioblastoma cells and block over 85% of their 3D invasion.

The paper uses in vivo single-cell gain-of-function screening to identify latent transcriptional programs that reprogram T cells into synthetic states with enhanced therapeutic potential.

This study shows that IL-18 enhances antitumor activity of CAR-NKT cells against neuroblastoma by promoting metabolic reprogramming and reducing exhaustion markers.

This study engineers CSPG4-targeting CAR-macrophages that inhibit melanoma growth in vitro and in vivo, showing promise for solid tumor immunotherapy.

This study shows CD32131R-CR T cells can eliminate EGFR-overexpressing cancer cells when combined with cetuximab or panitumumab, outperforming CD16158F-CR T cells.