Michael F. Coleman

This study shows obesity impairs B7-H3.CAR-T cell antitumor activity and memory formation in TNBC by altering cytokine profiles and metabolic function.

The paper identifies urinary metabolite signatures predictive of calorie restriction-mediated weight loss in obese mice, with sex-specific differences observed.

This study identifies obesity-driven inflammatory and metabolic transcriptomic signatures in mouse and human colon tumors through integrated transcriptomic analyses.

This study shows that intermittent energy restriction (IER) reduces tumor growth and improves paclitaxel response in a mouse model of endometrial cancer compared to low-fat diet.

This study shows that acetyl-CoA carboxylase (ACC) activity in T cells within the tumor microenvironment inhibits lipid utilization and energy synthesis, and its restriction enhances T cell survival and antitumor function.

This study shows tirzepatide reduces obesity-related tumor growth by improving metabolism and restoring CD8+ T cell function without directly targeting cancer cells.