Developmental BiologyMechanisms of DevelopmentPeer-reviewed
Gain-of-function Shh mutants activate Smo in cis independent of Ptch1/2 function
Catalina Casillas, Henk Roelink
The paper identifies Shh mutations that enable cell-autonomous activation of the Hh pathway via Smo, independent of Ptch1/2, and shows that unprocessed Shh pro-peptide can drive this activation.
10 citations