Cancer BiologybioRxivPreprint
Epigenetic inactivation of oncogenic brachyury (TBXT) by H3K27 histone demethylase controls chordoma cell survival
Lucia Cottone, Edward S Hookway, Adam Cribbs…·Adrienne M Flanagan
This study shows that inhibiting H3K27 demethylases reduces TBXT expression and kills chordoma cells by altering epigenetic marks and gene expression.
DOI 10.1101/432005