ImmunologyFrontiers in ImmunologyPeer-reviewed
Exploration of T-cell immune responses by expression of a dominant-negative SHP1 and SHP2
Julia Taylor, Anna M. Bulek, Isaac Gannon…·Simon Thomas
This study investigates the role of SHP1 and SHP2 in T-cell immunosuppression by expressing truncated variants and shows that dSHP2 can alleviate PD1-mediated suppression in CAR T cells.