Cancer BiologybioRxivPreprint
Onco-Circuit Addiction and Onco-Nutrient mTORC1 Signaling Vulnerability in a Model of Aggressive T Cell Malignancy
Xinxin Wang, Andrew E. Cornish, Mytrang Do…·Ming O. Li
The paper shows that mTORC1 signaling hypersensitivity to leucine drives an onco-circuit in T cell malignancy, and a low leucine diet is therapeutic without impairing T cell immunity.
DOI 10.1101/2024.04.03.587917