Global lengthening of 3′ untranslated regions of mRNAs by alternative cleavage and polyadenylation in cellular senescence
Miao Han, Guoliang Lv, Hongbo Nie, Ting Shen, Yichi Niu, Xueping Li, Meng Chen, Xia Zheng, Wei Li, Chen Ding, Gang Wei, Jun Gu, Xiao-Li Tian, Yufang Zheng, Xinhua Liu, , Ting Ni
This study shows that alternative polyadenylation (APA) leads to longer 3' UTRs in senescent cells, affecting gene regulation through miRNA and RBP binding sites.
bioRxiv · Dec 2, 2015 · PreprintGenomics