Author

Meng Chen

Guangzhou Laboratory

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Cell Biology· 2 Genomics· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Research Focus:differential expression· 2 Organism:rat· 2 Approach:statistical model· 2

Frequent Co-Authors

Chen Ding· 2 shared Gang Wei· 2 shared Guoliang Lv· 2 shared Hongbo Nie· 2 shared Jinfeng Hu· 2 shared Jun GuiD· 2 shared Miao Han· 2 shared Ting NiiD· 2 shared

Activity by Year

2015-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenomics

Chen Ding

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Dynamic dissociation of the IFT complex drives ciliary dysfunction during C. elegans ageing

Jiayi Li, Songyue Wang, Shengzhi Xie, Meng Chen, Mengjiao Song, Xiaona Zhang, Ji Tang, Qifu Li, Dong Li, Xiumin Yan, Yidong Shen

This study uses super-resolution imaging to show that IFT complexes in C. elegans cilia dynamically dissociate with age, leading to reduced IFT velocity and ciliary dysfunction.

bioRxiv · Apr 17, 2026 · PreprintCell Biology

A minor muscle stem cell population functions as metabolic Trojan horse fueling systemic aging by succinate induced epigenetic reprogramming

Xiaofen Wu, Meng Chen, Ruqi Fan, Hongye Wang, Ruimiao Ma, Xiaocui Tang, Hui Wang, Wei Wei, Jiemin Wong, Guoliang Xu, Ping Hu

This study identifies muscle stem cells as drivers of systemic inflammaging through succinate-induced epigenetic reprogramming, linking metabolic dysregulation to aging phenotypes.

bioRxiv · Dec 26, 2025 · PreprintCell Biology

Global lengthening of 3′ untranslated regions of mRNAs by alternative cleavage and polyadenylation in cellular senescence

Miao Han, Guoliang Lv, Hongbo Nie, Ting Shen, Yichi Niu, Xueping Li, Meng Chen, Xia Zheng, Wei Li, Chen Ding, Gang Wei, Jun Gu, Xiao-Li Tian, Yufang Zheng, Xinhua Liu, , Ting Ni

This study shows that alternative polyadenylation (APA) leads to longer 3' UTRs in senescent cells, affecting gene regulation through miRNA and RBP binding sites.

bioRxiv · Dec 2, 2015 · PreprintGenomics

Progressive lengthening of 3′ untranslated regions of mRNAs by alternative cleavage and polyadenylation in cellular senescence of mouse embryonic fibroblasts

Miao Han, Guoliang Lv, Hongbo Nie, Ting Shen, Yichi Niu, Xueping Li, Meng Chen, Xia Zheng, Wei Li, Chen Ding, Gang Wei, Jun Gu, Xiao-Li Tian, Yufang Zheng, Xinhua Liu, , Ting Ni

The paper investigates APA regulation in cellular senescence, finding genes in senescent cells preferentially use distal polyadenylation sites, associated with longer 3′ UTRs and senescence-related pathways.

bioRxiv · Nov 11, 2015 · PreprintGenomics