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Christian P. Dillard

James J. Peters VA Medical Center

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Genetics· 1

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Assay:GWAS summary statistics· 1 Research Focus:imputation· 1 Approach:statistical model· 1

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Gabriel E. HoffmaniD· 1 shared Kiran GirdhariD· 1 shared Panos RoussosiD· 1 shared

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Gabriel E. HoffmanORCID

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GeneticsPLoS GeneticsPeer-reviewedOct 28, 2026

Fast Probabilistic Whitening Transformation for Ultra-High Dimensional Genetic Data

Gabriel E. Hoffman, Christian P. Dillard, Kiran Girdhar, Panos Roussos

The paper introduces a probabilistic whitening transformation for high-dimensional genetic data, showing it is faster and more accurate than existing methods for imputing z-statistics and identifying genetic regulatory signals.

DOI 10.1371/journal.pgen.1012320

GWAS summary statisticsstatistical model

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