Molecular BiologyNature Chemical BiologyPeer-reviewed
Reversible histone deacetylase activity catalyzes lysine acylation
Takeshi Tsusaka, Mohd Altaf Najar, Benjamin H. Schwarz…·Emily L. Goldberg
The paper shows class I HDACs can catalyze beta-hydroxybutyrylation of lysine, a reversible modification, expanding the role of HDACs beyond traditional deacetylation.
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