Cancer BiologybioRxiv
XPA tumor variants lead to defects in NER that sensitize cells to cisplatin
Alexandra M Blee, Kaitlyn S Gallagher, Hyun-Suk Kim…·Walter J Chazin
This study identifies XPA tumor variants that impair NER, increasing cisplatin sensitivity, and provides mechanistic insights for variant effect prediction.
DOI 10.1093/narcan/zcae013