BiochemistrybioRxivPreprint
Programmable amide bond formation using de novo ligases
Saman Salike, Timo Fluegel, Maximilian Gantz…·David Baker
This study designs de novo amide ligases with a cysteine catalytic triad to selectively form amide bonds across diverse substrates, demonstrating high selectivity and applicability in synthesizing bioactive molecules.
DOI 10.64898/2026.11.08.765178