Andrew C. Hunt

This paper designs de novo ligases that achieve site-specific ubiquitylation of a target protein with high selectivity and efficiency.

This study designs de novo amide ligases with a cysteine catalytic triad to selectively form amide bonds across diverse substrates, demonstrating high selectivity and applicability in synthesizing bioactive molecules.

This study designs miniprotein inhibitors targeting bacterial adhesins to prevent and treat urinary tract infections.

This study designs novel serine hydrolases with high catalytic efficiency using computational methods, achieving structures close to design models and distinct from natural enzymes.

The paper designs and characterizes trivalent miniprotein binders that neutralize SARS-CoV-2 variants with low pM IC50 values and provide prophylactic and therapeutic protection in mice.

This paper develops an automated cell-free platform for rapid antibody discovery and screening, demonstrating its effectiveness with SARS-CoV-2 neutralizing antibodies.