Author

Christopher Cahill

Joslin Diabetes Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Assay:scRNA-seq· 2 Assay:spatial transcriptomics· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Alejandro PenaiD· 2 shared Cristina Aguayo‐MazzucatoiD· 2 shared Francesko HelaiD· 2 shared Francisco G. CigarroaiD· 2 shared George A. KucheliD· 2 shared Hui PaniD· 2 shared James L. KirklandiD· 2 shared Jeffrey H. ChuangiD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

Alejandro PenaORCID

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2 papers

Recent·Most cited

Distinct senescent β-cell senotypes differentially drive islet aging and dysfunction

Kanako Iwasaki, Hui Pan, Jonathan M. Dreyfuss, Maya Jackson, Sergii Domanskyi, Dylan Baker, Priscila Carapeto, Christopher Cahill, Sandra Le, Francesko Hela, Juliana Alcoforado Diniz, Giray Naim Eryilmaz, Fan Wu, Pei-Hsun Wu, Bofei Yu, , Cristina Aguayo‐Mazzucato

The paper identifies two distinct senescent β-cell subpopulations with different functional roles in islet aging and dysfunction using single-cell proteomics and transcriptomics.

bioRxiv · May 28, 2026 · PreprintCell Biology

A human and mouse subpopulation of senescent β-cells induces pathologic dysfunction through targetable paracrine signaling

Kanako Iwasaki, Priscila Carapeto, Cristian Abarca, Francesko Hela, Stephanie Sanjines, Sebastian Pena, Sandra M. Le, Hui Pan, Christopher Cahill, Ayush D. Midha, Juliana Alcoforado Diniz, Dylan S. Baker, Sergii Domanskyi, Sara Espinoza, Alejandro Pena, , Cristina Aguayo‐Mazzucato

The paper identifies senescent β-cell subpopulations in humans and mice that induce pathologic dysfunction through paracrine signaling and shows JAK inhibitors can reverse this effect.

bioRxiv · May 7, 2025 · PreprintDevelopmental Biology