Cancer BiologyCancer Gene TherapyPeer-reviewed
Tafazzin Mediates Tamoxifen Resistance by Regulating Cellular Phospholipid Composition in ER-Positive Breast Cancer
Xuan Li, Yuan Zhang, Tengjiang Zhang…·Hanqiu Zheng
This study identifies Tafazzin's role in tamoxifen resistance by regulating phospholipid composition in ER+ breast cancer cells, showing that TAZ depletion promotes resistance via an LPC-LPA axis.