Molecular BiologybioRxivPreprint
A Yeast-Based Screening System for Differential Identification of Poison Inhibitors and Catalytic Inhibitors of Human Topoisomerase I
Ahmed Seddek, Christian Madeira, Thirunavukkarasu Annamalai…·Yuk‐Ching Tse‐Dinh
This paper develops a yeast-based screening system to identify human TOP1 poison inhibitors and catalytic inhibitors, distinguishing their mechanisms and assessing cytotoxicity.
DOI 10.1101/2021.11.16.468530