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Christopher R. Neal

University of Bristol

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Synthetic Biology· 1

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Organism:bacteria (other)· 1 Approach:experimental assay· 1 Assay:protein sequence· 1 Assay:protein structure· 1

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Alexander T. HilditchiD· 1 shared Andrey V. RomanyukiD· 1 shared Derek N. WoolfsoniD· 1 shared Jennifer J. McManusiD· 1 shared Judith MantelliD· 1 shared Lorna R. HodgsoniD· 1 shared Louise C. SerpelliD· 1 shared Paul VerkadeiD· 1 shared

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Alexander T. HilditchORCID

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Synthetic BiologyJournal of the American Chemical SocietyPeer-reviewedApr 5, 2024

Maturation and conformational switching of a de novo designed phase-separating polypeptide

Alexander T. Hilditch, Andrey V. Romanyuk, Lorna R. Hodgson…·Derek N. Woolfson

This study describes a de novo designed polypeptide that forms phase-separated droplets and fibers, showing droplet maturation into β-conformations similar to pathological assemblies.

11 citations

bacteria (other)protein structure

𝕏 PostBluesky