BioinformaticsMolecular CellPeer-reviewed
DeorphaNN: Virtual screening of GPCR peptide agonists using AlphaFold-predicted active-state complexes and deep learning embeddings
Larissa Ferguson, Sébastien Ouellet, Elke Vandewyer…·Isabel Beets
DeorphaNN identifies peptide agonists for GPCRs using AlphaFold structural predictions and deep learning embeddings, successfully uncovering agonists for two orphan receptors across species.
DOI 10.1016/j.molcel.2026.07.006