Cancer BiologybioRxivPreprint
Epigenetic Reactivation of Lineage Differentiation to Target Leukemia
Shandon M Amos, Chi-Chao Chen, Yichen Xiang…·Yadira M. Soto‐Feliciano
This study identifies TRIM28 as a critical regulator in acute leukemia, showing its depletion promotes neutrophil differentiation and reduces leukemic potential, with a small-molecule inhibitor developed to target it.
DOI 10.64898/2026.07.08.737260