BiochemistryNature Structural & Molecular BiologyPeer-reviewed
FICD acts bi-functionally to AMPylate and de-AMPylate the endoplasmic reticulum chaperone BiP
Steffen Preissler, Claudia Rato, Luke Perera…·David Ron
This paper identifies FICD as the enzyme that both AMPylates and de-AMPylates BiP, revealing its dual functionality in regulating ER chaperone activity in response to stress.
DOI 10.1038/nsmb.3337