Author

Clementine Elwes

University College London

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Biophysics· 1

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Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

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Benjamin A. HalliD· 1 shared David ShorthouseiD· 1 shared Harris Lister· 1 shared Paul SmithiD· 1 shared Rachel AlcraftiD· 1 shared

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Benjamin A. HallORCID

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1 paper

Recent·Most cited

BiophysicsbioRxivPreprintNov 9, 2025

Validating folding energy estimates as a method for variant interpretation

Clementine Elwes, Rachel Alcraft, Harris Lister…·Benjamin A. Hall

This study validates folding energy estimates for variant interpretation, showing that while correlation coefficients are low, the method can improve prediction accuracy by identifying and addressing outlier residues.

DOI 10.1101/2025.11.09.687451

protein structuredeep learning

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