NeurosciencebioRxivPreprint
Age-dependent remodeling of the sciatic proteome in 5xFAD mice can be attenuated by exercise or donepezil treatment to maintain neuromuscular function
Matthew H. Brisendine, Dijanira Q. Nieves-Esparcia, Orion S Willoughby…·Joshua C. Drake
This study shows that exercise or donepezil treatment can reduce proteomic changes in sciatic nerves of 5xFAD mice, preserving neuromuscular function before cognitive decline.
DOI 10.1101/2025.07.01.662603