Nutrient-responsive midgut turnover is spatially controlled by serotonin signaling
Nicole Lamichane, Petteri Borgman, Terhi Rintakangas, Kateryna Gaertner, Marius Robciuc, Onur Deniz, Tuuli Kirkinen, Cornelia Biehler, Simon Andersson, Jenny Barlund, Oona Kinnunen, Pekka Katajisto, Jaakko Mattila, Ville Hietakangas
The paper shows serotonin signaling spatially controls nutrient-responsive midgut turnover in Drosophila by regulating enteroblast maturation and morphological changes through the 5HT7 receptor.
bioRxiv · Nov 4, 2026 · PreprintPhysiology