BiophysicsCirculation ResearchPeer-reviewed
The HCM-Linked Mutation Arg92Leu in TNNT2 Allosterically Alters the cTnC-cTnI Interface and Disrupts the PKA-mediated Regulation of Myofilament Relaxation
Melissa L. Lynn, Jesús Jiménez, Romi L. Castillo…·Jil C. Tardiff
This paper investigates how the HCM-linked mutation Arg92Leu in TNNT2 alters the cTnC-cTnI interface, impairing PKA access and causing early diastolic dysfunction.
3 citations