Author

Romi L. Castillo

University of ArizonaORCID 0000-0002-9383-7365Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Andrew KimiD· 1 shared Anne M. MurphyiD· 1 shared Anthony P. BaldoiD· 1 shared Catherine VasqueziD· 1 shared Cyonna Gibson· 1 shared Jesús JiméneziD· 1 shared Jil C. TardiffiD· 1 shared Matthew M. KlassiD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

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9 top collaborators · 36 mutual co-author links

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1 shared paperBiophysics

Andrew KimORCID

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1 paper

Recent·Most cited

BiophysicsCirculation ResearchPeer-reviewedSep 27, 2024

The HCM-Linked Mutation Arg92Leu in TNNT2 Allosterically Alters the cTnC-cTnI Interface and Disrupts the PKA-mediated Regulation of Myofilament Relaxation

Melissa L. Lynn, Jesús Jiménez, Romi L. Castillo…·Jil C. Tardiff

This paper investigates how the HCM-linked mutation Arg92Leu in TNNT2 alters the cTnC-cTnI interface, impairing PKA access and causing early diastolic dysfunction.

3 citations

humanproteomics

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