Author

D. A. Farnsworth

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Cancer Biology· 1

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

A. M. Unni· 1 shared D. Lu· 1 shared F. D. Johnson· 1 shared G. de Rappard-Yuswack· 1 shared M. Ladanyi· 1 shared R. Shi· 1 shared R. Somwar· 1 shared W. Lockwood· 1 shared

Activity by Year

2022-2022 · peak 1/yr

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9 top collaborators · 36 mutual co-author links

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1 shared paperCancer Biology

A. M. Unni

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1 paper

Recent·Most cited

MEK inhibitor resistance in lung cancer cells associated with addiction to sustained ERK suppression

D. A. Farnsworth, Y. Inoue, F. D. Johnson, G. de Rappard-Yuswack, D. Lu, R. Shi, R. Somwar, M. Ladanyi, A. M. Unni, W. Lockwood

The paper identifies drug addiction to MEK inhibitors in KRAS-mutant lung cancer cells, showing that resistance is linked to ERK suppression and KRAS amplification, suggesting therapeutic strategies involving drug holidays.

bioRxiv · Apr 29, 2022 · PreprintCancer Biology