Y. Inoue

Maternal high-fat diet affects the contents of eggs and causes abnormal development in the medaka fish

This study shows that maternal high-fat diet in medaka fish leads to egg content changes and increased embryonic deformities in offspring.

Deciphering mechanisms of UV filter- and temperature-induced bleaching in the coral Acropora tenuis, using ecotoxicogenomics

This study investigates the effects of UV filter BP-3 and thermal stress on coral Acropora tenuis using RNA-seq, identifying gene expression differences and potential markers for bleaching.

MEK inhibitor resistance in lung cancer cells associated with addiction to sustained ERK suppression

The paper identifies drug addiction to MEK inhibitors in KRAS-mutant lung cancer cells, showing that resistance is linked to ERK suppression and KRAS amplification, suggesting therapeutic strategies involving drug holidays.

Conserved GYXLI motif of FlhA is involved in dynamic domain motions of FlhA required for flagellar protein export

This study identifies the conserved GYXLI motif in FlhA as critical for dynamic domain motions in FlhAC, enabling efficient flagellar protein export via the fT3SS.

m6A demethylase ALKBH5 promotes tumor cell proliferation by destabilizing IGF2BPs target genes and worsens the prognosis of patients with non-small cell lung cancer

Identification of domestic cat hepadnavirus from a cat blood sample in Japan

The study identifies a domestic cat hepadnavirus infection in a Japanese cat, showing genetic differences from global strains.

Comprehensive-immunopeptidomics analysis reveals presentation of potential neoantigens carrying cancer driver mutations

This study identifies neoantigens with cancer driver mutations using immunopeptidomics techniques, revealing new potential targets for cancer immunotherapy.

Role of the N- and C-terminal regions of FliF, the MS ring component in Vibrio flagellar basal body

This study investigates the roles of N- and C-terminal regions of FliF in Vibrio flagellar MS ring formation and function, finding that the N-terminus aids in ring formation via FlhF interaction while the C-terminus is essential for motor function.

Extracellular signal-regulated kinase mediates chromatin rewiring and lineage transformation in lung cancer

This study identifies the ERK-CBP/p300-ETS axis as promoting lineage transformation between neuroendocrine and non-neuroendocrine lung cancer subtypes through chromatin rewiring.

RhoGAP19D inhibits Cdc42 laterally to control epithelial cell shape and prevent invasion

The paper identifies RhoGAP19D as a Cdc42 GTPase Activating Protein that restricts Cdc42 activity to the apical domain, preventing epithelial invasion.

The FlhA linker mediates flagellar protein export switching during flagellar assembly

The paper identifies FlhA's linker as a switch that regulates flagellar protein export specificity during assembly by interacting with FlhAC to control chaperone binding.

Clinical evaluation of presepsin considering renal function.

This study recalculates the reference range for presepsin considering renal function, finding it significantly lower than the standard range and correlated with renal biomarkers.

Constrained actin dynamics emerges from variable compositions of actin regulatory protein complexes

The paper shows that heterogeneous actin regulatory complexes can produce stable filopodia-like structures through stochastic dynamics.