R. Shi

Compensatory mutations potentiate constructive neutral evolution by gene duplication

The paper duplicates and evolves an homodimeric enzyme to show that compensatory mutations can lead to functional heteromers through subfunctionalization.

Dairy practices select for thermostable endolysins in phages

The paper shows that dairy practices have selected for thermostable endolysins in phages infecting Streptococcus thermophilus, reducing endolysin diversity.

Single-cell transcriptome analysis on the anatomic positional heterogeneity of pig skin

The paper analyzes single-cell transcriptomes of pig skin from six anatomical regions to characterize cellular heterogeneity and identify candidate genes for ECM accumulation.

Behavioral pattern separation and cognitive flexibility are enhanced in a mouse model of increased lateral entorhinal cortex-dentate gyrus circuit activity

This study shows that increasing lateral entorhinal cortex-dentate gyrus circuit activity in mice improves behavioral pattern separation and cognitive flexibility, along with increased neurogenesis.

Shape-shifting microgel automata controlled by DNA sequence instructions

The paper demonstrates DNA-controlled microgel automata that transform between complex shapes using designed DNA sequences and neural networks.

The intrinsically disordered cytoplasmic tail of a dendrite branching receptor uses two distinct mechanisms to regulate the actin cytoskeleton

This study identifies two distinct mechanisms by which the intrinsically disordered cytoplasmic tail of HPO-30 regulates actin dynamics during dendrite branching in C. elegans.

MEK inhibitor resistance in lung cancer cells associated with addiction to sustained ERK suppression

The paper identifies drug addiction to MEK inhibitors in KRAS-mutant lung cancer cells, showing that resistance is linked to ERK suppression and KRAS amplification, suggesting therapeutic strategies involving drug holidays.

Impact of various vaccine boosters on neutralization against Omicron following prime vaccinations with inactivated or adenovirus-vectored vaccine

This study evaluates the effectiveness of various vaccine boosters against the Omicron variant following prime vaccinations with inactivated or adenovirus-vectored vaccines, finding that certain boosters significantly enhance neutralizing activity.

Intestinal SEC16B modulates obesity by controlling dietary lipid absorption

This study shows that intestinal SEC16B is essential for dietary lipid absorption, with its loss protecting mice from obesity.

Integrative multi-omics landscape of non-structural protein 3 of severe acute respiratory syndrome coronaviruses

This study uses multi-omics analyses to investigate the functions of NSP3 proteins from SARS-CoV and SARS-CoV-2, revealing their roles in RNA metabolism and immune response.

Bcl-xL restricts transcriptional, morphological and functional decompensation of β-cell mitochondria under chronic glucose excess

This study shows that Bcl-xL prevents mitochondrial dysfunction in beta-cells under chronic glucose stress by limiting mitochondrial ROS and maintaining gene expression.

A novel small molecule that induces cytotoxicity in lung cancer cells inhibits disulfide reductases GSR and TXNRD1

The paper identifies LCS3, a compound that induces oxidative stress in lung cancer cells by inhibiting disulfide reductases GSR and TXNRD1, and shows its synergistic effect with glutathione and thioredoxin pathway inhibition.

ZHX2 Promotes HIF1α Oncogenic Signaling in Triple-Negative Breast Cancer

This study identifies ZHX2 as a promoter of HIF1α oncogenic signaling in TNBC, showing its role in cell growth, invasion, and metastasis through interaction with HIF1.

Neuroprotective mechanisms of red clover and soy isoflavones in Parkinson's disease models

This study shows that isoflavones from red clover and soy protect neurons and reduce motor deficits in Parkinson's disease models.

Loss of HOXB13 expression in neuroendocrine prostate cancer

The paper shows HOXB13 expression is reduced or lost in neuroendocrine prostate cancer (NEPCa) and that NEPCa tumors lose prostate-specific HOX codes without gaining a clear new tissue identity.

Ultra-sensitive nanozyme-based chemiluminescence paper test for rapid diagnosis of SARS-CoV-2 infection

This paper develops a rapid, sensitive, and low-cost nanozyme-based chemiluminescence paper test for SARS-CoV-2 antigen detection with results in under 16 minutes.

The expression of YAP1 is increased in high-grade prostatic adenocarcinoma but is reduced in neuroendocrine prostate cancer

This study shows YAP1 is increased in high-grade prostate adenocarcinoma but reduced in neuroendocrine prostate cancer, with YAP1 loss activating Wnt/beta-Catenin signaling linked to NEPC development.

Zinc-independent activation of Toll-like receptor 4 by S100A9

This study shows that S100A9 can activate TLR4 without requiring Zn2+ binding, challenging previous assumptions about the role of zinc in this interaction.

A pipeline for multidimensional confocal analysis of mitochondrial morphology, function and dynamics in pancreatic β-cells

The paper develops a pipeline and ImageJ plugin for 2D/3D quantification of mitochondrial morphology and dynamics in mouse β-cells using standard confocal microscopy.

Immune Landscape of Invasive Ductal Carcinoma Tumour Microenvironment Identifies a Prognostic and Immunotherapeutically Relevant Gene Signature

The paper identifies an immune signature in invasive ductal carcinoma that predicts prognosis and response to immunotherapy.