D. Alansary

A better brain? Alternative spliced STIM2 in hominoids arises with synapse formation and creates a gain-of-function variant

The paper identifies a unique STIM2 variant in hominoids that enhances SOCE and may contribute to brain complexity evolution.

Plasma Membrane Calcium ATPase (PMCA) Regulates Stoichiometry of CD4+ T-cell Compartments

The paper shows PMCA4 regulates CD4+ T-cell compartment stoichiometry via Ca2+ levels, with YY1 controlling PMCA4 expression to modulate immune responses.

Collagen density defines 3D migration of CTLs and their consequent cytotoxicity against tumor cells

This study shows that dense collagen matrices impair CTL migration and cytotoxicity, with microtubule networks playing a key role in restoring migration and function.

Cytotoxic efficiency of human CD8+ T cell memory subtypes

This study quantifies the cytotoxic efficiency of human TEM and TCM CD8+ T cell subtypes, finding TEM cells are more effective in inducing apoptosis and necrosis due to higher perforin expression and more efficient lytic synapses.

High glucose attenuates Ca2+ influx in cytotoxic T lymphocytes upon target recognition

This study shows high glucose increases store-operated calcium entry but reduces calcium influx during target recognition in CTLs, leading to increased necrosis after killing.

Supra-molecular assemblies of ORAI1 at rest precede local accumulation into punctae after activation

This study uses liquid phase electron microscopy to show that ORAI1 forms supra-molecular clusters at rest, which amplify ORAI1 accumulation into punctae upon SOCE activation.