M. Hoth

Pancreatic islets undergo functional and morphological adaptation during development of Barth Syndrome

The paper investigates how defective cardiolipin remodeling in Barth Syndrome affects pancreatic islet function and metabolism, finding improved glucose tolerance and compensatory metabolic adaptations in a mouse model.

T cell polarization and NFAT translocation are stiffness-dependent and are differentially regulated by Piezo1 and Orai1

This study shows that T cell polarization and NFAT translocation are stiffness-dependent and are regulated by different Ca2+ influx pathways, Piezo1 and Orai1.

PIEZO1-mediated mechanosensing governs NK cell killing efficiency and infiltration in three-dimensional matrices

This study shows that PIEZO1-mediated mechanosensing affects NK cell killing efficiency and infiltration in 3D matrices by responding to tumor cell stiffness.

A noval lightsheet scattering microscopy for long-term visualization of cell-ECM interaction

This paper introduces a novel lightsheet scattering microscopy technique to visualize long-term cell-ECM interactions in 3D without photobleaching.

High glucose enhances antigen-independent CTL killing via TRAIL

This study shows high glucose increases TRAIL expression in CTLs, promoting beta cell apoptosis, and identifies metformin and vitamin D as synergistic therapies to mitigate this effect.

Collagen density defines 3D migration of CTLs and their consequent cytotoxicity against tumor cells

This study shows that dense collagen matrices impair CTL migration and cytotoxicity, with microtubule networks playing a key role in restoring migration and function.

Cytotoxic efficiency of human CD8+ T cell memory subtypes

This study quantifies the cytotoxic efficiency of human TEM and TCM CD8+ T cell subtypes, finding TEM cells are more effective in inducing apoptosis and necrosis due to higher perforin expression and more efficient lytic synapses.

Identification of molecular candidates which regulate calcium-dependent CD8+ T-cell cytotoxicity

The paper identifies four molecular candidates that regulate Ca2+-dependent CD8+ T-cell cytotoxicity through transcriptome analysis and functional assays.

Interdependence of CTL and NK cells cytotoxicity against melanoma cells

This study examines how CTL and NK cells interact to kill melanoma cells, showing that their cytotoxicity is interdependent and that resistance mechanisms vary based on pre-exposure conditions.

Optoregulated force application to cellular receptors using molecular motors

This paper introduces a light-driven molecular motor system to apply forces to cellular receptors, demonstrating its ability to manipulate cell adhesion and activation.

Migration of Cytotoxic T Lymphocytes in 3D Collagen Matrices

This study investigates the migration patterns of CD8+ T cells in 3D collagen matrices, identifying three motility types and proposing a two-state model to explain their movement through ECM.