An ex vivo human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy
X. Zhang, R. D. Pechous, P. A. Malaviarachchi, S. K. Banerjee, S. Byrum, D. Alkam, A. Ghaffarieh, R. C. Kurten, J. L. Kennedy
This paper establishes an ex vivo human precision-cut lung slice platform to study SARS-CoV-2 infection, immune responses, and drug efficacy, identifying key cytokines and viral RNA persistence as important features of COVID-19.
bioRxiv · Apr 18, 2023 · PreprintMicrobiology