Author

D. B. Jaffe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

W. J. McDonnell· 3 shared A. E. Royall· 2 shared A. M. Chrisman· 2 shared B. A. Adams· 2 shared D. S. Reyes· 2 shared F. Tsai· 2 shared N. Raman· 2 shared P. M. Finnegan· 2 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

W. J. McDonnell

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Author profile →

3 papers

Recent·Most cited

Deep repertoire mining uncovers ultra-broad coronavirus neutralizing antibodies targeting multiple epitopes

J. Hurtado, T. F. Rogers, D. B. Jaffe, B. Adams, S. Bangaru, E. Garcia, T. Capozzola, T. Messmer, P. Sharma, G. Song, N. Beutler, W. He, K. Dueker, R. Musharrafieh, M. J. T. Stubbington, , B. Briney

The paper identifies two broadly neutralizing antibodies against coronaviruses by screening B cell repertoires, showing they target different epitopes and offer protection against variants.

bioRxiv · Mar 28, 2023Immunology

Functional antibodies exhibit light chain coherence

D. B. Jaffe, P. Shahi, B. A. Adams, A. M. Chrisman, P. M. Finnegan, N. Raman, A. E. Royall, F. Tsai, T. Vollbrecht, D. S. Reyes, W. J. McDonnell

The paper shows that functional antibodies have a high probability of using the same light chain V gene, termed light chain coherence, unlike naive antibodies.

bioRxiv · Apr 23, 2022Immunology

enclone: precision clonotyping and analysis of immune receptors

D. B. Jaffe, P. Shahi, B. A. Adams, A. M. Chrisman, P. M. Finnegan, N. Raman, A. E. Royall, F. Tsai, T. Vollbrecht, D. S. Reyes, W. J. McDonnell

enclone computes approximate clonotypes from single-cell data, demonstrating high specificity with a probability of co-clonotyping unrelated B cells around 10^-9.

bioRxiv · Apr 21, 2022 · PreprintImmunology