Author

T. Vollbrecht

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. E. Royall· 2 shared A. M. Chrisman· 2 shared B. A. Adams· 2 shared D. B. Jaffe· 2 shared D. S. Reyes· 2 shared F. Tsai· 2 shared N. Raman· 2 shared P. M. Finnegan· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

A. E. Royall

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Functional antibodies exhibit light chain coherence

D. B. Jaffe, P. Shahi, B. A. Adams, A. M. Chrisman, P. M. Finnegan, N. Raman, A. E. Royall, F. Tsai, T. Vollbrecht, D. S. Reyes, W. J. McDonnell

The paper shows that functional antibodies have a high probability of using the same light chain V gene, termed light chain coherence, unlike naive antibodies.

bioRxiv · Apr 23, 2022Immunology

enclone: precision clonotyping and analysis of immune receptors

D. B. Jaffe, P. Shahi, B. A. Adams, A. M. Chrisman, P. M. Finnegan, N. Raman, A. E. Royall, F. Tsai, T. Vollbrecht, D. S. Reyes, W. J. McDonnell

enclone computes approximate clonotypes from single-cell data, demonstrating high specificity with a probability of co-clonotyping unrelated B cells around 10^-9.

bioRxiv · Apr 21, 2022 · PreprintImmunology

Nef enhances HIV-1 replication and infectivity independently of SERINC3 and SERINC5 in CEM T cells

P. W. Ramirez, T. Vollbrecht, F. M. Acosta, M. Suarez, A. A. Angerstein, J. Wallace, R. M. O'Connell, J. Guatelli

This study shows that HIV-1 Nef enhances replication and infectivity in CEM T cells without relying on SERINC3 or SERINC5 antagonism.

bioRxiv · Jul 15, 2020Microbiology

Vaccine Elicitation of HIV Broadly Neutralizing Antibodies from Engineered B cells

D. Huang, J. T. Tran, A. Olson, T. Vollbrecht, M. V. Guryleva, M. Tenuta, R. P. Fuller, T. Schiffner, J. R. Abadejos, L. Couvrette, T. R. Blane, K. Saye, W. Li, E. Landais, A. Gonzalez-Martin, , J. E. Voss

This study shows that engineered HIV bnAb-expressing B cells can be expanded in vivo after vaccination, leading to durable bnAb memory and long-lived plasma cells.

bioRxiv · Mar 17, 2020Immunology