P. Sharma

A generative reference grammar of healthy TCR repertoires reveals cancer-associated immune remodeling

CRAFT, a transformer model, learns a generative grammar of healthy TCR repertoires to detect cancer-associated immune remodeling through structured deviations in sequence space.

Genotypic and Phenotypic Analyses Show Ralstonia solanacearum Cool Virulence is a Quantitative Trait Not Restricted to 'Race 3 biovar 2'

The paper analyzes genotypic and phenotypic data to show that cool virulence in Ralstonia solanacearum is a quantitative trait not exclusive to R3bv2 strains.

Lysosomal signaling pathways influence heart rhythm, and regulate atrial function

This study investigates the role of lysosomal Ca2+ signaling in heart rhythm and atrial function, finding that NAADP pathway inhibition affects SAN pacemaker activity and cAMP production in atrial myocytes.

Exploring Probiotic Potential: A Comparative Genomics and In Silico Assessment of Genes within the Genus Geobacillus

This study assesses the probiotic potential of Geobacillus by analyzing its genomic features, revealing safety traits and absence of virulence factors.

Method for isolation of small extracellular vesicles from different biofluids and workflow for Mass Spectrometry based-shotgun proteomics and RNA isolation

The paper develops an improved ultracentrifugation method for isolating small extracellular vesicles from biofluids and demonstrates its use for proteomics and RNA isolation.

Targeting LxCxE cleft pocket of retinoblastoma protein in M2 macrophages inhibits ovarian cancer progression

This study shows targeting the LxCxE cleft pocket of Rb in M2 macrophages inhibits ovarian cancer progression by reducing immunosuppressive TAMs and enhancing T cell infiltration.

An early, novel arginine methylation of KCa3.1 attenuates subsequent T cell exhaustion.

The paper shows that early arginine methylation of KCa3.1 limits Ca2+-mediated NFAT1 activation, preventing T cell exhaustion during activation.

The effect of molnupiravir and nirmatrelvir on SARS-CoV-2 genome diversity in severe models of COVID-19.

This study examines how molnupiravir and nirmatrelvir affect SARS-CoV-2 genome diversity in immunocompromised mice, finding reduced viral load and specific mutations but no major consensus sequence changes.

Theileria annulata Infection Promotes p53 suppression, Genomic Instability and DNA deaminase APOBEC3H upregulation leading to cancer-like phenotype in host cells

This study identifies somatic mutations and genomic instability in Theileria annulata-infected leukocytes, linking them to cancer-like phenotypes through ROS1, TP53 suppression, and APOBEC3H upregulation.

H-NS is a bacterial transposon capture protein

This study identifies H-NS as a transposon capture protein that directs transposition to specific chromosomal regions, affecting phenotypic diversity and gene function in bacteria.

PPARγ mediated enhanced lipid biogenesis fuels Mycobacterium tuberculosis growth in a drug-tolerant hepatocyte environment.

This study shows Mtb induces PPARγ in hepatocytes to create lipid droplets and drug-tolerant environments, contributing to systemic pathogenicity and metabolic impairments during TB infection.

Peribacillus frigoritolerans T7-IITJ, a potential biofertilizer, induces plant growth-promotinggenes of Arabidopsis thaliana

This study identifies Peribacillus frigoritolerans T7-IITJ as a biofertilizer that promotes plant growth and drought tolerance by inducing specific genes in Arabidopsis thaliana.

Contextual and Combinatorial Structure in Sperm Whale Vocalisations

This study identifies contextual and combinatorial structure in sperm whale vocalizations, revealing a complex communication system with features similar to human language.

A mitochondrial quality control mechanism reverses the phagosome maturation arrest caused by Mycobacterium tuberculosis

This study identifies a mitochondrial quality control mechanism that reverses phagosome maturation arrest caused by Mycobacterium tuberculosis through RAB7 recruitment and lysosomal targeting.

A Novel AI-Designed Antimicrobial Peptide Synergistically Potentiates Aminoglycosides against Colistin- and Carbapenem-Resistant Acinetobacter baumannii

This study designs AI-generated antimicrobial peptides that synergize with aminoglycosides to combat colistin- and carbapenem-resistant Acinetobacter baumannii, showing potent antibacterial activity and biofilm eradication.

Ly6G+Granulocytes-derived IL-17 limits protective host responses and promotes tuberculosis pathogenesis

This study identifies IL-17 and COX2 as negative regulators of protective immunity in tuberculosis, showing that Ly6G+ granulocytes are a major source of IL-17 and their inhibition reduces bacterial burden and pathology.

The lipid Gb3 promotes germinal center B cell responses and anti-viral immunity

The paper shows that Gb3 lipid on GC B cells enhances antibody affinity and breadth, promoting cross-protective immunity against influenza.

Molecular pathways and cellular subsets associated with adverse clinical outcomes in overlapping immune-related myocarditis and myositis

The paper uses single-cell RNA sequencing to identify molecular pathways and immune subsets in immune-related myocarditis and myositis, finding clonally expanded CD8+ T cells and specific myeloid cell populations associated with adverse outcomes.

Stumpy forms are the predominant transmissible forms of Trypanosoma brucei.

This study compares the infectivity of slender and stumpy bloodstream forms of Trypanosoma brucei in adult tsetse flies, finding stumpy forms more effective in infecting immune competent flies.

Recombinant SARS-CoV-2 lacking initiating and internal methionine codons within ORF10 is attenuated in vivo

This study shows that a recombinant SARS-CoV-2 virus lacking ORF10 start and internal methionine codons is attenuated in hamsters, with reduced lower respiratory tract viral titre and increased reversion to wild-type.

Protein kinase PfPK2 mediated signalling is critical for host erythrocyte invasion by malaria parasite

This study identifies PfPK2 as a critical kinase for malaria parasite invasion of erythrocytes by regulating microneme protein release, cGMP, and calcium signaling.

Enantioselectivity in the Enzymatic Dehydration of Malate and Tartrate: Mirror Image Specificities of Structurally Similar Dehydratases

This study investigates the enantiomer-specificity of two structurally similar enzymes, FH and L-TTD, revealing evolutionary divergence in their substrate stereospecificity preferences.

Hyperglycosylation of prosaposin in tumor DCs promotes immune escape in cancer

This study shows that hyperglycosylation of prosaposin in tumor DCs leads to immune escape by impairing antigen presentation and T cell activation.

Atomic structure of wheat ribosome reveals unique features of the plant ribosomes

The paper presents high-resolution cryo-EM structures of wheat ribosomes and identifies unique features compared to other eukaryotes.

Chromatin conformation dynamics during CD4+ T cell activation implicates autoimmune disease-associated genes and regulatory elements

The paper identifies autoimmune disease-associated genes and regulatory elements by analyzing chromatin dynamics during CD4+ T cell activation using RNA-seq, ATAC-seq, and HiC.

Methotrimeprazine exerts antiviral and neuroprotective effects in Japanese encephalitis virus infection through activation of adaptive ER stress and autophagy

This study identifies Methotrimeprazine as a drug that reduces JEV infection through autophagy and ER stress, with neuroprotective and antiviral effects in a mouse model.

Deep repertoire mining uncovers ultra-broad coronavirus neutralizing antibodies targeting multiple epitopes

The paper identifies two broadly neutralizing antibodies against coronaviruses by screening B cell repertoires, showing they target different epitopes and offer protection against variants.

FLAgellum Member 8 modulates extravascular distribution of African trypanosomes.

This paper identifies FLAM8 as a flagellar protein that modulates extravascular dissemination of Trypanosoma brucei in mammalian hosts, without affecting transmissible stage differentiation.

A comparison of methods to suppress electrocardiographic artifacts in local field potential recordings

This study compares ECG suppression methods in LFP recordings to recover brain activity, finding that SVD methods offer the best balance between artifact removal and signal preservation.

Myeloid-specific KDM6B inhibition sensitizes Glioblastoma to PD1 blockade

This study shows that inhibiting KDM6B in myeloid cells improves response to PD1 blockade in glioblastoma by enhancing anti-tumor immunity.