E. Garcia

The N-terminus of Plasmodium falciparum Circumsporozoite Protein Contains Three Non-Overlapping Murine B-cell Epitope Regions

This study identifies three non-overlapping B-cell epitope regions in the N-terminus of Plasmodium falciparum CSP using monoclonal antibodies from immunized mice.

Deep repertoire mining uncovers ultra-broad coronavirus neutralizing antibodies targeting multiple epitopes

The paper identifies two broadly neutralizing antibodies against coronaviruses by screening B cell repertoires, showing they target different epitopes and offer protection against variants.

Neglected no longer: Phylogenomic resolution of higher-level relationships in Solifugae

This study generates a phylogenomic dataset for Solifugae using ultraconserved elements, revealing a well-resolved phylogeny and divergence times, supporting a diversification history driven by continental breakup.

In situ single-cell analysis of canonical breast cancer biomarkers: phenotypic heterogeneity and implications on response to HER2 targeting agents.

The paper analyzes HER2-positive breast cancer tumors at the single-cell level to identify phenotypic heterogeneity and its implications for response to HER2-targeted therapies.

Robust, single-shot, optical autofocus system utilizing cylindrical lenses to provide high precision and long range of operation

This paper introduces an optical autofocus system with high precision and long range for microscopy, demonstrating its use in multiwell plate imaging and single molecule localization microscopy.

Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause severe disease

The paper identifies broadly neutralizing antibodies targeting the S2 region of betacoronavirus spikes that protect against SARS-CoV-1, SARS-CoV-2, and MERS-CoV.

Targeted isolation of panels of diverse human protective broadly neutralizing antibodies against SARS-like viruses

This study isolates a panel of broadly neutralizing antibodies against SARS-like viruses from donors, showing effectiveness against multiple variants including Omicron.

Single-shot phase contrast microscopy using polarisation-resolved differential phase contrast

The paper introduces a single-shot differential phase microscopy technique using a polarisation-sensitive camera to simultaneously acquire images for phase gradient and quantitative phase calculations.

A Calcium/Palmitoylation Switch Interfaces the Signaling Networks of Stress Response and Transition to Flowering

The paper identifies a calcium/palmitoylation switch mechanism that regulates flowering time and stress adaptation in plants by controlling the nuclear localization of SOS3/CBL4.

Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques

This study shows that rhesus macaques can be immunized to produce broadly neutralizing antibodies against multiple SARS-related viruses, highlighting differences in B cell repertoires between humans and macaques.

A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection

This study identifies a broadly neutralizing antibody that targets a conserved site on beta-coronavirus spike proteins and provides protection against SARS-CoV-2 infection.

Robust optical autofocus system utilizing neural networks trained for extended range and time-course and automated multiwell plate imaging including single molecule localization microscopy

The paper develops a neural network-based autofocus system for microscopy, improving accuracy and range for long-term and multiwell plate imaging.

Sequence-function relationships in phage-encoded bacterial cell wall lytic enzymes and their implications for phage-derived products design

This study analyzes phage-encoded lysin sequences to identify structural and physicochemical features associated with their function against Gram-negative bacteria, revealing genetic specialization and providing a database for further research.

Rapid isolation of potent SARS-CoV-2 neutralizing antibodies and protection in a small animal model

This study rapidly identifies potent SARS-CoV-2 neutralizing antibodies and demonstrates their protective efficacy in an animal model.

The ciliary membrane of polarized epithelial cells stems from a midbody remnant-associated membrane patch with condensed nanodomains

The paper identifies a midbody remnant-associated membrane patch that contributes to ciliary membrane formation in polarized epithelial cells.

Dissecting single cell molecular spatiotemporal mobility and clustering at Focal Adhesions in polarised cells by fluorescence fluctuation spectroscopy methods

The paper uses fluorescence fluctuation spectroscopy to analyze molecular dynamics at focal adhesions in polarized cells, showing differential self-assembly dynamics and antero-posterior gradients.

Polarity sensitive probes for super resolution STED microscopy

This study evaluates polarity-sensitive dyes in super resolution STED microscopy to probe nanoscale membrane heterogeneity in cell-derived vesicles, live cells, and virus particles.