Author

D. B. Silva

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Approach:statistical model· 2 Approach:deep learning· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

A. A. Thomas· 1 shared A. Schlessinger· 1 shared C. Clausen· 1 shared C. Macdonald· 1 shared D. Mitrovic· 1 shared D. Trinidad· 1 shared J. Bohlke· 1 shared J. S. Witte· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiophysics

A. A. Thomas

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Author profile →

2 papers

Recent·Most cited

The full spectrum of OCT1 (SLC22A1) mutations bridges transporter biophysics to drug pharmacogenomics

S. W. Yee, C. Macdonald, D. Mitrovic, X. Zhou, M. Koleske, J. Yang, D. B. Silva, P. R. Grimes, D. Trinidad, S. S. More, L. Kachuri, J. S. Witte, L. Delemotte, K. M. Giacomini, W. Coyote-Maestas

This study examines OCT1 mutations to understand their impact on drug response and identifies population-specific allele frequencies linked to LDL cholesterol levels.

bioRxiv · Jun 6, 2023 · PreprintBiophysics

Describing Inhibitor Specificity for the Amino Acid Transporter LAT1 from Metainference Simulations

K. Hutchinson, D. B. Silva, J. Bohlke, C. Clausen, A. A. Thomas, M. Bonomi, A. Schlessinger

This study uses metainference MD simulations, molecular docking, and experiments to identify critical residues and druggable pockets in LAT1, leading to the discovery of new inhibitors.

bioRxiv · May 3, 2022Biophysics