GFI1 cooperates with IKAROS/IKZF1 to activate gene expression in T-cell acute lymphoblastic leukemia
M. E. Engel, W. Sun, J. Guo, D. McClellan, A. Poeschla, D. Bareyan, M. J. Casey, B. R. Cairns, D. Tantin
The paper identifies a non-canonical transcriptional mechanism in T-ALL where GFI1 and IKAROS cooperate to transactivate NOTCH3, independent of LSD1 binding.
bioRxiv · Mar 8, 2021Biochemistry