J. Guo

BOOST: a robust ten-fold expansion method on hour-scale

BOOST is a rapid expansion microscopy method that achieves ~10x linear expansion in 90 minutes using microwave-assisted chemistry, improving throughput for various biological specimens.

Sarm1 Gates the Transition from Protective to Repair Schwann Cell States Following Nerve Injury

This study shows Sarm1 promotes the transition from protective to repair Schwann cell states after nerve injury, with implications for neuropathies and neurodegenerative diseases.

Strawberry COP9 signalosome FvCSN5A regulates plant development and fruit ripening by facilitating polyamine oxidase FvPAO5 degradation to control polyamine and H2O2 homeostasis

This study identifies FvCSN5A as a regulator of polyamine and H2O2 homeostasis in strawberries by controlling FvPAO5 degradation, affecting plant development and fruit ripening.

Targeting NOTCH2-JAG1 juxtacrine signaling reverses macrophage-mediated tumor resistance to taxol

This study identifies NOTCH2-JAG1 juxtacrine signaling as a target to reverse macrophage-mediated taxane resistance in ovarian cancer by sensitizing tumors to paclitaxel.

Linalool's Multifaceted Antimicrobial Potential: Unveiling its Antimicrobial Efficacy and Immunomodulatory Role Against Saprolegnia parasitica

This study investigates linalool's antimicrobial and immunomodulatory effects against S. parasitica, showing it disrupts cell membranes, inhibits protein synthesis, and enhances host immune responses.

Directed Micro-Ecology Application System: On-site One-step Fermentation Facilitating Microbial Application through Theoretical and Equipment Innovation

The paper introduces a directed micro-ecology system with an intelligent fermentor that enhances microbial stability and effectiveness across multiple applications.

RUNX2 Isoform II Protects Cancer Cells from Ferroptosis and Apoptosis by Promoting PRDX2 Expression in Oral Squamous Cell Carcinoma

This study identifies RUNX2 isoform II as a suppressor of ferroptosis and apoptosis in OSCC by upregulating PRDX2 via the HOXA10/RUNX2 isoform II/PRDX2 pathway.

Fast adaptive super-resolution lattice light-sheet microscopy for rapid, long-term, near-isotropic subcellular imaging

This paper introduces Meta-rLLS-VSIM, a super-resolution microscopy technique that achieves near-isotropic resolution with reduced training time and data requirements.

Glutamate (E299) is a key residue in the evolutionarily divergence of the SAM-dependent methyltransferases DnrK and RdmB in anthracycline biosynthesis

The paper identifies residue E299 as critical for the divergent catalytic functions of DnrK and RdmB in anthracycline biosynthesis, revealing distinct mechanisms for 10-hydroxylation and 4-O-methylation.

Ancient cyanobacterial proto-circadian clock adapted to short day-night cycles ~ 0.95 billion years ago

The paper reconstructs an ancient cyanobacterial circadian clock from ~0.95 billion years ago and shows it adapts to 18-h day-night cycles but lacks endogenous oscillation.

TLR2 Supports γδ T cell IL-17A Response to ocular surface commensals by Metabolic Reprogramming

This study identifies Vγ6 T cells as a major C. mast-responsive subset in the conjunctiva and shows that intrinsic TLR2 signaling drives metabolic reprogramming and IL-17A production.

Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells

This study shows that Piezo1 in intestinal L cells mechanically regulates GLP-1 production, affecting glucose tolerance and diabetes.

WWP2 MEDIATES THE METABOLIC REPROGRAMMING OF RENAL MYOFIBROBLASTS TO PROMOTE KIDNEY FIBROSIS

This paper identifies WWP2 as a regulator of myofibroblast metabolic reprogramming in renal fibrosis, showing it suppresses PGC-1 to alter metabolic pathways and reduce fibrosis severity.

GGCX promotes Eurasian avian-like H1N1 swine influenza virus adaption to interspecies receptor binding

This study identifies GGCX as a key factor enabling EA H1N1 SIV adaptation to human-type -2,6 sialic acid receptors through HA carboxylation, suggesting it as a potential antiviral target.

Granzyme B-based CAR T cells block metastasis by eliminating circulating tumor cells

This study develops GrB-CAR T cells targeting mHSP70 to eliminate CTCs and inhibit metastasis in solid tumors.

The SAS Chromatin-Remodeling Complex Mediates Inflorescence-Specific Chromatin Accessibility for Transcription Factor Binding

The SAS chromatin-remodeling complex establishes inflorescence-specific chromatin accessibility at distal promoter and upstream intergenic regions, enabling transcription factor binding during flower development.

Mapping protein-metabolite interactions in E. coli by integrating chromatographic techniques and co-fractionation mass spectrometry.

The paper introduces PROMIS, a co-fractionation mass spectrometry technique integrated with chromatographic methods to map protein-metabolite interactions in E. coli, identifying 994 interactions and revealing novel functional insights.

In-silico Drug Repurposing pipeline for Epilepsy: Integrating Deep Learning and Structure-based Approaches

This paper develops an in-silico drug repurposing pipeline for epilepsy using deep learning and structure-based methods, identifying potential drugs with high binding affinity for epilepsy-related targets.

Cell Type Specific Responses of the Endoplasmic Reticulum Dynamics to Environmental Stress

This study develops a super-resolution imaging and analysis method to study ER dynamics in Arabidopsis under environmental stress, revealing correlations between ER structure parameters and growth features.

LRG1 promotes atherosclerosis by activating macrophages

This study identifies LRG1 as a pro-inflammatory factor in atherosclerosis by promoting macrophage M1 polarization through ERK and JNK pathways, and shows that LRG1 inhibition reduces atherosclerosis progression.

Root-specific secondary metabolism at the single-cell level: a case study of theanine metabolism and regulation in the roots of tea plants (Camellia sinensis)

This study uses scRNA-seq to analyze theanine metabolism in tea plant roots, revealing multicellular compartmentation of biosynthesis without high co-expression of transcription factors.

Early evolution of the ecdysozoan body plan

The paper describes a new Cambrian ecdysozoan species, Beretella spinosa, and suggests that ancestral ecdysozoans may have been non-vermiform.

Liver cancer initiation is dependent on metabolic zonation but decoupled from premalignant clonal expansion

This study shows that liver cancer initiation depends on metabolic zonation but is not linked to premalignant clonal expansion.

Target-aware Molecule Generation for Drug Design Using a Chemical Language Model

This paper introduces TamGen, a chemical language model for target-aware molecule generation, and shows it produces high-quality compounds with inhibitory activity against Tuberculosis ClpP protease.

Effects of greening-induced warming and cooling on tree phenology in temperate and boreal forests

This study shows forest greening alters tree phenology by causing earlier spring and autumn events through seasonal biophysical warming and cooling effects.

The phosphoproteome is a first responder in tiered cellular adaptation to chemical stress followed by proteomics and transcriptomics alteration

This study compares transcriptomics, proteomics, and phosphoproteomics responses in HepG2 and AC16 cells to chemical exposure, finding phosphoproteomics changes occur earlier and at lower concentrations than transcriptomics.

Mechanical Resistance to Micro-Heart Tissue Contractility unveils early Structural and Functional Pathology in iPSC Models of Hypertrophic Cardiomyopathy

This study uses iPSC-derived heart tissue models to show that mechanical stress exacerbates HCM-linked MYBPC3 mutations, leading to structural and functional cardiac pathology.

Metabolic interactions of a minimal bacterial consortium drive robust nitritation at acidic pH

This study identifies a minimal bacterial consortium that efficiently drives nitritation at acidic pH through metabolic interactions and stress adaptation mechanisms.

Ultrasensitive and multiplexed protein imaging with clickable and cleavable fluorophores

This paper develops a highly sensitive and multiplexed in situ protein profiling method using click chemistry and cleavable fluorophores, enabling the quantification of 28 proteins in FFPE tissue and classification of over 820,000 cells.

Dual Ethanolamine Head Groups in Ionizable Lipids Facilitate Phospholipid-free Stable Nanoparticle Formulation for Augmented and Safer mRNA Delivery

This paper introduces ionizable lipids with dual ethanolamine head groups for phospholipid-free mRNA delivery, showing improved stability, efficiency, and reduced toxicity.