Author

M. J. Casey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

B. R. Myers· 2 shared R. A. Stewart· 2 shared A. B. Long· 1 shared A. Lee· 1 shared A. Poddar· 1 shared A. Poeschla· 1 shared A. W. Tucker· 1 shared B. R. Cairns· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCancer Biology

B. R. Myers

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Author profile →

4 papers

Recent·Most cited

A Simple and Scalable Zebrafish Model of Sonic Hedgehog Medulloblastoma

M. J. Casey, P. P. Chan, Q. Li, C. A. Jette, M. Kohler, B. R. Myers, R. A. Stewart

This paper develops a zebrafish model of Sonic Hedgehog medulloblastoma by mutating ptch1 and identifies grk3 as a target for tumor formation.

bioRxiv · Feb 3, 2024Cancer Biology

GRK2 Kinases in the Primary Cilium Initiate SMOOTHENED-PKA Signaling in the Hedgehog Cascade

M. F. Walker, J. Zhang, W. Steiner, P.-I. Ku, J.-F. Zhu, Z. Michaelson, Y.-C. Yen, A. Lee, A. B. Long, M. J. Casey, A. Poddar, I. B. Nelson, C. D. Arveseth, F. Nagel, R. Clough, , B. R. Myers

This study identifies GRK2-mediated phosphorylation of SMO in the primary cilium as a critical step initiating SMO-PKA signaling in the Hedgehog pathway.

bioRxiv · May 10, 2023Cell Biology

GFI1 cooperates with IKAROS/IKZF1 to activate gene expression in T-cell acute lymphoblastic leukemia

M. E. Engel, W. Sun, J. Guo, D. McClellan, A. Poeschla, D. Bareyan, M. J. Casey, B. R. Cairns, D. Tantin

The paper identifies a non-canonical transcriptional mechanism in T-ALL where GFI1 and IKAROS cooperate to transactivate NOTCH3, independent of LSD1 binding.

bioRxiv · Mar 8, 2021Biochemistry

Genome reduction is associated with bacterial pathogenicity across different scales of temporal and ecological divergence

G. G. R. Murray, J. Charlesworth, E. L. Miller, M. J. Casey, C. T. Lloyd, M. Gottschalk, A. W. Tucker, J. J. Welch, L. A. Weinert

The paper investigates whether genome reduction is linked to bacterial pathogenicity across different scales of divergence and finds it consistently associated with reduced genome size in pathogens.

bioRxiv · Jul 3, 2020Evolutionary Biology