PTPN14, a modifier of HHT, protects SMAD4 from ubiquitination and turnover to potentiate BMP9 signaling in endothelial cells.
O. MAMAI, D. Beleford, M. Taylor, S. Basu, X. Cen, S. Trilok, J. Zhang, A. Balmain, R. Akhurst
This study identifies PTPN14 as a stabilizer of SMAD4, enhancing BMP9 signaling in endothelial cells and suggesting potential drug targets for HHT.
bioRxiv · Sep 29, 2021 · PreprintCell Biology