Dynamics of Collagen Oxidation and Cross Linking in Regenerating and Irreversibly Infarcted Myocardium
E. A. Akam, D. Bergemann, S. J. Ridley, S. To, B. Andrea, B. Moon, H. Ma, Y. Zhou, A. Aguirre, P. Caravan, J. M. Gonzalez-Rosa, D. E. Sosnovik
The paper develops fluorescent probes to study collagen oxidation and cross-linking in mouse and zebrafish myocardium, finding that mature cross-links form in mouse scars but not in zebrafish, potentially enabling regeneration.
bioRxiv · Jul 25, 2023 · PreprintBiochemistry