H. Ma

An Omni-Mesoscope for multiscale high-throughput quantitative phase imaging of cellular dynamics and high-content molecular characterization

The paper introduces the Omni-Mesoscope, a cost-effective imaging platform that combines quantitative phase microscopy and multiplex fluorescence imaging to study cellular dynamics and molecular characteristics.

Spatially Resolved Tumor Ecosystems and Cell States in Gastric Adenocarcinoma Progression and Evolution

This study integrates spatial transcriptomics and single-cell data from gastric cancer samples to reveal tumor ecosystem dynamics, evolutionary trajectories, and immune microenvironment features.

Biophysical Profiling of Red Blood Cells from Thin-film Blood Smears using Deep Learning

This paper develops a deep learning model to detect RBC deformability and storage-related changes in blood smears, showing high accuracy in categorizing deformability groups.

Positive Selection on Rare Variants Underlying the Cold Adaptation of Wild Boar

This study identifies rare variants under positive selection in wild boar linked to cold adaptation, showing convergent molecular evolution with humans.

A Deep Learning-Driven Sampling Technique to Explore the Phase Space of an RNA Stem-Loop

This paper adapts a deep learning-driven sampling technique for RNA stem-loop folding, showing it can efficiently explore phase space with lower computational cost than traditional methods.

Spatially resolved niche and tumor microenvironmental alterations in gastric cancer peritoneal metastases

This study identifies transcriptomic and immune features of gastric cancer peritoneal metastases, highlighting predictive markers and therapeutic targets in the tumor microenvironment.

Granzyme B-based CAR T cells block metastasis by eliminating circulating tumor cells

This study develops GrB-CAR T cells targeting mHSP70 to eliminate CTCs and inhibit metastasis in solid tumors.

Steatotic liver disease induced by TCPOBOP-activated hepatic constitutive androstane receptor: Primary and secondary gene responses with links to disease progression

This study investigates TCPOBOP-induced steatotic liver disease in mice, identifying primary and secondary gene responses linked to disease progression and potential biomarkers.

Structural and functional basis of VLDLR receptor usage by Eastern equine encephalitis virus

This study identifies multiple VLDLR binding sites used by EEEV and develops a decoy receptor to neutralize infection.

Distinct functions of EHMT1 and EHMT2 in cancer chemotherapy and immunotherapy

This study shows EHMT1 and EHMT2 have distinct roles in cancer therapy, with EHMT1 affecting DNA replication and alkylating agents, while EHMT2 influences immunotherapy response via STING expression.

ADAR2 inhibits ER-targeted mRNA translation via regulating nucleolar assembly of signal recognition particle

This study shows ADAR2 inhibits ER-targeted mRNA translation by regulating SRP assembly in the nucleolus without requiring RNA binding or A-to-I editing.

Dynamics of Collagen Oxidation and Cross Linking in Regenerating and Irreversibly Infarcted Myocardium

The paper develops fluorescent probes to study collagen oxidation and cross-linking in mouse and zebrafish myocardium, finding that mature cross-links form in mouse scars but not in zebrafish, potentially enabling regeneration.

Intestinal LKB1 loss drives a pre-malignant program along the serrated cancer pathway

This study shows that LKB1 loss in intestinal cells leads to a pre-malignant state linked to serrated colorectal cancer, which is amplified by loss-of-heterozygosity.

The tRNA Gm18 Methyltransferase TARBP1 Promotes Hepatocellular Carcinoma Progression via Metabolic Reprogramming of Glutamine

This study identifies TARBP1 as a driver gene in hepatocellular carcinoma that promotes tumor progression by methylating tRNA and enhancing glutamine metabolism.

Genome duplications, genomic conflict, and rapid phenotypic evolution characterize the Cretaceous radiation of Fagales

This study examines the relationship between phenotypic and genomic evolution in Fagales, finding an 'early burst' model of diversification linked to gene duplication and genomic conflict during the Cretaceous.

CytoSIP: An annotated structural atlas for interactions involving cytokine or cytokine receptor

CytoSIP provides a database of cytokine-cytokine receptor interactions with SNPs, interfaces, and disease associations to aid drug design and precision medicine.

ATP is a major determinant of phototrophic bacterial longevity in growth arrest.

This study shows that ATP depletion leads to cell death in Rhodopseudomonas palustris during growth arrest, while ATP-replete conditions allow long-term survival.

Tailored chemical reactivity probes for systemic imaging of aldehydes in fibroproliferative diseases

This paper develops three Mn(II)-based MR probes to image aldehydes in fibroproliferative diseases, showing improved relaxivity and noninvasive detection of tissue fibrogenesis in mouse models.

Spatiotemporal Genomic Profiling of Intestinal Metaplasia Reveals Clonal Dynamics of Gastric Cancer Progression

This study analyzes genomic and transcriptomic data from gastric samples to identify driver genes and clonal dynamics in intestinal metaplasia, showing their progression to gastric cancer and the role of microbial dysbiosis.

Nucleolar structure connects with global nuclear organization

This study shows that disrupting nucleolar structure in HeLa cells affects global nuclear organization, including changes in genomic loci and nuclear bodies, independent of ribosome synthesis inhibition.

Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stresses

The paper identifies acetate as a novel energy stress marker produced in the liver via ACOT12/8-mediated conversion of acetyl-CoA from fatty acids, supporting its role in brain fueling and CoA recycling.

The cryptic step in biogeochemical Tellurium (Te) cycle: Indirect elementary Te oxidation mediated by manganese-oxidizing bacterium (MnOB)

This paper identifies a previously overlooked process where manganese-oxidizing bacteria oxidize elemental tellurium, challenging the assumption of Te0 stability in wastewater treatment.

Design, evaluation and implementation of synthetic isopentyldiol pathways in Escherichia coli

The paper designs and evaluates synthetic isopentyldiol pathways in E. coli, finding that a computationally designed pathway produces IPDO at 2.2 mg/L from glucose.

Exosome-mediated viral nucleic acid presentation in a crustacean reveals innate immunity evolution from a novel perspective

The paper shows that DNA virus components are packaged into exosomes by infected crustacean cells, which transmit apoptotic signals to suppress viral spread.

Long-term passaging of replication competent pseudo-typed SARS-CoV-2 reveals the antiviral breadth of monoclonal and bispecific antibody cocktails

This study evaluates the antiviral breadth of monoclonal and bispecific antibody cocktails against SARS-CoV-2 variants using a replication competent VSV-SARS-CoV-2 model, showing resistance to mutation in two cocktails.

Inhibition of CHK2 dependent DNA damage response suppresses Zika virus infection through a STING dependent mechanism

This study shows that inhibiting CHK2 reduces ZIKV production and rescues developmental defects by enhancing STING-dependent antiviral responses.

Conserved and divergent peptide substrate binding properties of bacterial Hsp70

The paper identifies native peptide substrates for bacterial Hsp70 DnaK, finding conserved and divergent binding properties among them, with VP5 showing potential as an antibacterial lead.

Call patterns encode and transmit emotion in marmoset monkeys

The paper analyzes marmoset monkey vocalizations to show that call patterns encode emotional states and transmit emotion between individuals.

Ticagrelor combined with aspirin displays the signature of regulating the gut microbiome in consistence with improving the immuno-inflammatory response in atherosclerosis

The paper was withdrawn due to insufficient cell culture data to clarify the mechanism of ticagrelor and aspirin's effect on the gut microbiome and immuno-inflammatory response in atherosclerosis.

Hetero-bivalent Nanobodies Provide Broad-spectrum Protection against SARS-CoV-2 Variants of Concern including Omicron

This paper develops hetero-bivalent nanobodies that neutralize multiple SARS-CoV-2 variants, including Omicron, and show protective effects in vivo.